Senolytics have the unique ability to eliminate senescent cells - aged cells the promote organ deterioration.
When cells accumulate enough damage, especially to DNA, they enter a dormant state called senescence. Senescent cells emit a collection of molecules known as the senescence-associated secretory phenotype (SASP), which includes pro-inflammatory molecules and enzymes that destroy tissue. Senescent cells accumulate with age and, in high numbers, begin to slowly deteriorate the organs they inhabit. Moreover, the deleterious SASP factors includes molecules that stimulate surrounding cells to enter senescence. Thus, senescent cell accumulation promotes tissue degradation and chronic inflammation, which can lead to accelerated aging.
Senescent cells are thought to exist to prevent the spread of tumorigenic cells and aid in wound healing. Unlike normal cells, they can evade programmed cell death (apoptosis). In young, healthy individuals with strong immune systems, senescent cells are eliminated by specialized immune cells. However, our immune systems weaken with age, allowing senescent cells to escape these immune cells and accumulate in numbers. By the time people have reached old age, senescent cells have accumulated throughout the organs of the body, causing inflammation and damage to surrounding cells and tissues. Scientists from leading institutions who study aging believe that senescent cell buildup is one of the primary reasons we age.
Senolytics Prune Senescent Cells
Researchers in the last decade have proposed that removing senescent cells may offer a therapeutic solution to complications arising from their accumulation. They have identified a new class of molecule known as senolytics that destroy these apoptosis-evading cells to reduce inflammation and improve tissue function. Many of these senolytics naturally occur in plants and have been concentrated to achieve doses with therapeutic effects.
Benefits of Senolytics and Senomorphics
Studies have shown that mice exhibit health and lifespan improvement along with SASP reductions from removing senescent cells. Notably, researchers have developed a class of compounds called senomorphics, specifically designed to target SASP factors. Together, targeting both senescent cells and SASP factors with senolytics and senomorphics can potentially mitigate senescent cell progression in a superior fashion than either alone.
Current evidence from animal studies shows that senolytics clear senescent cells and improve vascular aging while reducing cholesterol levels. Senolytics have also been shown to prevent arterial plaque buildup. In animal studies, senolytics have been shown to slow skin aging and help with the progressive degeneration of the joints that negatively impact health.
López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013). The hallmarks of aging. Cell, 153(6), 1194-1217.
van Deursen, J. M. (2014). The role of senescent cells in ageing. Nature, 509(7501), 439-446.
Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., … & Zhu, Y. (2016). Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice. Aging cell.
Childs, B. G., Baker, D. J., Wijshake, T., Conover, C. A., Campisi, J., & van Deursen, J. M. (2016). Senescent intimal foam cells are deleterious at all stages of atherosclerosis. Science, 354(6311), 472-477.
Palmer, A. K., Tchkonia, T., LeBrasseur, N. K., Chini, E. N., Xu, M., & Kirkland, J. L. (2015). Cellular senescence in type 2 diabetes: a therapeutic opportunity. Diabetes, 64(7), 2289-2298.
Velarde, M. C., & Demaria, M. (2016). Targeting Senescent Cells: Possible Implications for Delaying Skin Aging: A Mini-Review. Gerontology.
Xu, M., Bradley, E. W., Weivoda, M. M., Hwang, S. M., Pirtskhalava, T., Decklever, T., … & Lowe, V. (2016). Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, glw154.
Lluc Mosteiro, Cristina Pantoja, Noelia Alcazar et al. (2016) Tissue damage and senescence provide critical signals for cellular reprogramming in vivo. Science, 354(6315).
Demaria, M., Ohtani, N., Youssef, S. A., Rodier, F., Toussaint, W., Mitchell, J. R., … & Hoeijmakers, J. H. (2014). An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA. Developmental cell, 31(6), 722-733.
Tominaga, K. (2015). The emerging role of senescent cells in tissue homeostasis and pathophysiology. Pathobiology of Aging & Age-Related Diseases, 5.
Matjusaitis, M., Chin, G., Sarnoski, E. A., & Stolzing, A. (2016). Biomarkers to identify and isolate senescent cells. Ageing research reviews, 29, 1-12.
*The statements on this website have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
RESTORIN®, Seragon, and the Seragon logo are trademarks owned by or licensed to the Seragon group of companies. All other product names, brands, and logos are the property of their respective owners.